How should Wesleyans integrate modern understandings of science with theological commitments to the idea of original sin? After offering some historical context for Wesley’s engagement with the doctrine of original sin, this article aims to put contemporary socio- scientific discussions. The authority of scripture is engaged in light of Wesley’s “analogy of faith” and James K. A. Smith’s “Narrative-Arc” theological method. Insights of evolutionary psychology and sociobiology are then combined with Wesley’s understanding of universal human sinfulness and regenerating grace. The article explores Wesley’s holistic theological anthropology and contemporary emergence theory in their respective attempts to understand sin’s nefarious substance and power. Finally, the author notes additional theological considerations and concludes with a call to embrace John Wesley’s “catholic spirit.”