In a recent piece for the Asbury Theological Journal, Nathan Crawford has attempted to put current understandings of emergent phenomena within the neurosciences in conversation with Christian soteriology; in particular, Crawford has sought to link up themes found in emergence with distinctively Wesleyan perspectives on sanctification. In this article, I offer some reflections on theological methodology in light of Crawford's analysis, and I identify some needed clarifications of Kenneth J. Collins's model of John Wesley's soteriology. In the latter half of the piece, I present a critical analysis of the issue of monergism and synergism in Wesley's understanding of grace.