The following is a lecture delivered on 6 October 2005 as part of the Theta Phi Lecture Series at Asbury Theological Seminary, Wilmore, Kentucky As a Christian response to Islam, it covers several topics in relatively brief fashion. In the evangelistic encounter, the goal of which is a holistic encounter, the Christian must keep in mind the social-religious dynamics ofMuslims and incorporate this knowledge into a missiologically healthy approach that is built on a sound epistemological foundation. In short, for both a Christian response to Islam and evangelism of Muslims, Christians must possess a solid epistemology as foundational to "a theology that is missiologically informed, and a missiology that is theologically based." This further includes utilizing the texts of Muslims, specifically the Qur'an and the Hadith, as well as proclaiming core Christian doctrines. Pertaining to these latter points, the lecture addresses the doctrines of the deity of Christ, the Trinity, and the eternal nature of the Qur'an as it pertains to the issue of interpretation. It concludes with thoughts on the events of 11 September 2001 in the light of the teachings of the Qur'an and the Hadith.